Robert George BOYLE,David Winter WALKER,Richard Justin BOYCE
申请号：
US16606934
公开号：
US20200247796A1
申请日:
2018.04.27
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The invention provides compounds of the formula (3):or a pharmaceutically acceptable salt or tautomer thereof, wherein:Z is a 5-membered heteroaryl ring containing one or two nitrogen ring members and optionally one further heteroatom ring member selected from N and O；ring X is a benzene or pyridine ring；ring Y is a benzene, pyridine, thiophene or furan ring；Ar1 is an optionally substituted benzene, pyridine, thiophene or furan ring；m is 0, 1 or 2；n is 0, 1 or 2；R1 is selected from various substituents:R2 is selected from hydrogen and a C1-4 hydrocarbon group；R3 is selected from hydrogen and a C1-4 hydrocarbon group；R4 is selected from various substituents；R5 is selected from various substituents；Ar2 is an optionally substituted phenyl, pyridyl or pyridone group；R6 is a group Q1-Ra—；Rb；Q1 is absent or is a C1-3 saturated hydrocarbon linker；Ra is selected from O； C(O)； C(O)O； CONRc； N(Rc)CO； N(Rc)CONRc, NRc； and SO2NRc；Rb is selected from hydrogen and various substituents；and R7 is selected from R4.The compounds are useful in the treatment of cancers.
