It is intended to provide a dendritic cell for effectively activating and/or proliferating ³ ´ T cells in vivo and/or in vitro； a drug containing the same； a therapeutic method using the dendritic cell； and a method of culturing ³ €´ T cells using the dendritic cell. An immature dendritic cell originating in peripheral monocyte is pulsed with a bisphosphonate-base bone metabolism-improving agent to thereby impart an ability to activate r ´ T cells. Then it is cultured with cells containing ³ ´ T cells to thereby activate and/or proliferate the ³ ´ T cells. Thus, ³ ´ T cells can be easily proliferated without placing a burden to a patient, which makes it possible to practically carry out an immunological cell therapy with the use of ³ ´ T cells.
