Herein are reported anti-ANG2 antibodies. A specific anti-ANG2 antibody comprises (a) a HVR-H1 comprising the amino acid sequence of SEQ ID NO: 29, (b) a HVR-H2 comprising the amino acid sequence of SEQ ID NO: 30, and (c) a HVR-H3 comprising the amino acid sequence of SEQ ID NO: 32.本文報導抗ANG2抗體。一種特異性抗ANG2抗體包含(a)包含胺基酸序列SEQ ID NO:29之HVR-H1;(b)包含胺基酸序列SEQ ID NO:30之HVR-H2;及(c)包含胺基酸序列SEQ ID NO:32之HVR-H3。