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Antigen binding molecule that binds EGFR, vector encoding the same and use thereof
专利权人:
ロシュ グリクアート アクチェンゲゼルシャフト
发明人:
ウマナ,パブロ,エッケハルト,メスナー,ウマナ,パブロ,エッケハルト,メスナー
申请号:
JP2013038450
公开号:
JP5763695B2
申请日:
2013.02.28
申请国别(地区):
JP
年份:
2015
代理人:
摘要:
The present invention relates to antigen binding molecules (ABMs). In particular embodiments, the present invention relates to recombinant monoclonal antibodies, including chimeric, primatized or humanized antibodies specific for human EGFR. In addition, the present invention relates to nucleic acid molecules encoding such ABMs, and vectors and host cells comprising such nucleic acid molecules. The invention further relates to methods for producing the ABMs of the invention, and to methods of using these ABMs in treatment of disease. In addition, the present invention relates to ABMs with modified glycosylation having improved therapeutic properties, including antibodies with increased Fc receptor binding and increased effector function.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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