The present invention relates to a method for protecting a kidney, which comprises administering an extracellular polysaccharide produced by Ceriporia lacerata a mycelial culture medium of Ceriporia lacerata containing the extracellular polysaccharide dried powders of the mycelial culture medium or an extract of the mycelial culture medium, in an effective amount, to a subject in need of protecting a kidney. The method is effective in protecting a kidney from renal toxicity caused by an anti-cancer agent.