Hadasit Medical Research Services &； Development Limited
发明人:
Dimitrios KARUSSIS,Ibrahim KASSIS
申请号：
US16410516
公开号：
US20190264172A1
申请日:
2019.05.13
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Provided is a method of inducing transdifferentiation of mesenchymal stem cells (MSC), the method including (a) culturing MSC in a first culture medium including a growth factor selected for allowing formation of neuralized MSC (NMSC)； (b) allowing the NMSC to proliferate for a sufficient time during which said culture medium is renewed at least once； and (c) culturing the NMSC of (b) in a second culture media including cerebrospinal fluid (CSF) for a time sufficient for the NMSC to differentiate into a population of cells including terminally differentiated neurons, astrocytes and oligodendrocytes. Also provided by the present invention is the use of MSC or NMSC for providing a composition including said population and to kits including MSC or NMSC and instructions for use of same.
