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DERIVES D'OXADIAZOLE ET DE PYRIDAZINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPIE
专利权人:
SANOFI
发明人:
FETT, EYKMAR,MOUGENOT, PATRICK,NAMANE, CLAUDIE,NICOLAI, ERIC,PHILIPPO, CHRISTOPHE
申请号:
CA2806271
公开号:
CA2806271A1
申请日:
2011.07.22
申请国别(地区):
CA
年份:
2012
代理人:
摘要:
The invention relates to compounds of formula (I): in which: n is equal to 0 or 1; D represents an oxygen atom or a bond; W represents a nitrogen atom or a -CH- group; X1 represents a nitrogen atom or a -CH=CH- group; X2 represents an oxygen atom or a nitrogen atom; X3 represents an oxygen atom or a nitrogen atom; one of X1, X2, X3 being other than a nitrogen atom, X2 and X3 not being an oxygen atom at the same time; R1, R2 are absent or represent, (i) independently of one another, a hydrogen atom or a (C1 -C4)alkyl group, (ii) R1 and R2 may form, with the carbon atom to which they are attached, a -(C3-C10)cycloalkyl- group; Y represents a -(C3-C10)cycloalkyl-, aryl or aryloxy group, said groups being optionally substituted with one or more substituents chosen from a halogen atom or a (C1 -C6)alkoxy group; Z1 is absent or represents an -NH- function; Z2 and Z3 are as defined in the description. The invention also relates to a process for preparing compounds of formula (I), compositions containing them and their application in therapeutics.
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