LAMARCHE, MATTHEW, J.,BUSHELL, SIMON,PATANE, MICHAEL, A.,WHITEHEAD, LEWIS
申请号：
MYPI 20084727
公开号：
MY146920A
申请日:
2007.05.30
申请国别(地区):
MY
年份:
2012
代理人:
摘要：
THE PRESENT INVENTION IS DIRECTED TO COMPOUNDS, E.G., THIOPEPTIDE COMPOUNDS, AND INTERMEDIATES THERETO, AS WELL AS PHARMACEUTICAL COMPOSITIONS CONTAINING THE COMPOUNDS FOR USE IN TREATMENT OF BACTERIAL INFECTION. THE PRESENT INVENTION IS ALSO DIRECTED TO THE COMPOUNDS OF THE INVENTION OR COMPOSITIONS THEREOF AS MODULATORS OF THE ELONGATION FACTOR EF-TU. THE COMPOUNDS ARE PARTICULARLY USEFUL IN INTERFERING WITH THE LIFE CYCLE OF BACTERIA AND IN TREATING OR PREVENTING A BACTERIAL INFECTION OR PHYSIOLOGICAL CONDITIONS ASSOCIATED THEREWITH. THE PRESENT INVENTION IS ALSO DIRECTED TO METHODS OF COMBINATION THERAPY FOR INHIBITING EF-TU ACTIVITY IN CELLS, OR FOR TREATING OR PREVENTING A BACTERIAL INFECTION IN PATIENTS USING THE COMPOUNDS OF THE INVENTION OR PHARMACEUTICAL COMPOSITIONS, OR KITS THEREOF.
