A system includes an imaging device that captures multichannel image data from a region of interest on a patient, one or more processors, and memory storing instructions. The memory storing instructions cause the one or more processors to receive the multichannel image data from the imaging device, such that the multichannel image data includes an image signal representative of plethysmographic waveform data for the region of interest and specular noise in the multichannel image data. Furthermore, the memory storing instructions cause the one or more processors to generate a projection matrix associated with the multichannel image data and iterate values of the projection matrix to remove the specular noise to generate a representative physiological signal, such that the representative physiological signal has an improved signal-to-noise ratio relative to the image signal and the representative physiological signal is a representative plethysmographic waveform. The memory storing instructions cause the one or more processors to also calculate one or more physiological parameters using the representative physiological signal and output the one or more physiological parameters on a display.
