СКОТТ Ричард В. (US),ЛЮ Дахой (US),КАВАШ Роберт В. (US),ЯНГ Тревор (US),МАЛРУНИ Кэрол (US),КОСТАНЦО Майкл Дж. (US)
申请号：
RU2012133562/04
公开号：
RU2012133562A
申请日:
2011.01.05
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: each X is, independently, NR each Y is C = O Roznachaet each independently hydrogen or alkyl each optionally Ayavlyaetsya zameschennymarilenom or optionally substituted geteroarilenom and each Aoznachaet (CH) -, wherein q is 1 to 7, wherein the Au Anezavisimo optionally substituted with one or more PL-group (s), one or more NPL-group (s) or a combination of one or more PL-group (s) and one or more NPL-group (s), is hydrogen, PL-NPL-group or a group and Ryavlyaetsya -XAYR, wherein R is hydrogen, PL-NPL-group or a group iliRi means are each, independently, hydrogen, PL-NPL-group or a group iliRi Rvmeste is a single bond iliRyavlyaetsya -YAXR, wherein R is hydrogen, PL-NPL-group or a group and R is hydrogen, PL-NPL-group or a group ilikazhdaya group NPL means independently, -B (OR) or - (NR) -U-LK- (NR) -R, wherein: each R, r and Roznachaet independently hydrogen, alkyl, or alkoxy each r and Roznachaet independently hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl or heteroaryl where each of alkyl, alkenyl, alkynyl, cycloalkyl, aryl and heteroaryl optionally substituted with one or more substituents, wherein each substituent is independently alkyl, halo or haloalkyl each U are independently absent or represents O, S, S (= O), S (= O), NR, -C (= O) -, -C (= O) -NR-, -C (= O) -N = N-NR-, -C (= O) -NR-N = N-, -N = N-NR-, -C (= NN (R)) -, -C (= NR) -, -C ( = O) O-, -C (= O) S-, -C (= S) -, -OP (= O) O-, -SC = N- or -C (= O) -NR-O-, wherein groups with two chemically nonequivalent ends can receive both possible configurations LKoznachaet each, independently, - (CH ) - or Calkenilenil, wherein each - (CH) - and Calkenilenila optionally substituted with one or more substituents, wherein each substituent on
