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COMBINED THERAPY 238
- 专利权人:
- АСТРАЗЕНЕКА АБ (SE)
- 发明人:
- ЮРГЕНСМАЙЕР Юлиане (GB),СПИК Джорджина (GB)
- 申请号：
- RU2010138647/15
- 公开号：
- RU2010138647A
- 申请日:
- 2009.02.20
- 申请国别(地区):
- RU
- 年份:
- 2012
- 代理人:
- 摘要：
- 1. A combination product that contains a VEGFR tyrosine kinase inhibitor or a pharmaceutically acceptable salt thereof and an mTOR selective kinase inhibitor or a pharmaceutically acceptable salt thereof, in combination with a pharmaceutically acceptable adjuvant, diluent or carrier. ! 2. The combined product according to claim 1, containing 4- (4-fluoro-2-methyl-1H-indol-5-yloxy) -6-methoxy-7- (3- (pyrrolidin-1-yl) propoxy) quinazoline or a pharmaceutically acceptable salt thereof, and an mTOR selective kinase inhibitor, or a pharmaceutically acceptable salt thereof, in combination with a pharmaceutically acceptable adjuvant, diluent or carrier! where the mTOR selective kinase inhibitor is selected from any of the compounds! 5- [2,4-bis [3-methylmorpholin-4-yl] pyrido [5,6-e] pyrimidin-7-yl] -2-methoxy-N-methylbenzamide； ! 4- [2,4-bis [3-methylmorpholin-4-yl] pyrido [5,6-e] pyrimidin-7-yl] aniline； ! 6- [2,4-bis [3-methylmorpholin-4-yl] pyrido [5,6-e] pyrimidin-7-yl] -1H-indazol-3-amine； ! 8- [2,4-bis [3-methylmorpholin-4-yl] pyrido [5,6-e] pyrimidin-7-yl] -1,2,3,4-tetrahydro-1,4-benzodiazepin-5- he； ! 5- [2,4-bis [3-methylmorpholin-4-yl] pyrido [5,6-e] pyrimidin-7-yl] -2-methoxy-N-methylbenzamide； ! 5- [2,4-bis [3-methylmorpholin-4-yl] pyrido [5,6-e] pyrimidin-7-yl] pyridin-2-amine； ! N- [3- [2,4-bis [3-methylmorpholin-4-yl] pyrido [5,6-e] pyrimidin-7-yl] phenyl] methanesulfonamide； ! 3- [2,4-bis [3-methylmorpholin-4-yl] pyrido [5,6-e] pyrimidin-7-yl] aniline； ! 5- [2,4-bis [3-methylmorpholin-4-yl] pyrido [6,5-d] pyrimidin-7-yl] -2-ethoxybenzamide； ! 5- [2,4-bis [3-methylmorpholin-4-yl] pyrido [5,6-e] pyrimidin-7-yl] -2- (difluoromethoxy) -N-methylbenzamide； ! 5- [2,4-bis [3-methylmorpholin-4-yl] pyrido [5,6-e] pyrimidin-7-yl] -1H-indazol-3-amine； ! [5- [2,4-bis [3-methylmorpholin-4-yl] pyrido [5,6-e] pyrimidin-7-yl] -2-methoxyphenyl] methanol； ! N - [[4- [2,4-bis [3-methylmorpholin-4-yl] pyrido [5,6-e] pyrimidin-7-yl] phenyl]1. Комбинированный продукт, который со
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- 中国工程科技知识中心
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- http://www.ckcest.cn/home/
