Pharmaceutical formulations comprise sustained-release zonisamide. Methods of preparing such pharmaceutical formulations involve intermixing zonisamide with a suitable excipient configured to control the dissolution profile of the zonisamide. Methods of treatment involve administering the pharmaceutical formulations to patients in need of such treatment.本發明係關於包含持續釋放唑尼沙胺之醫藥調配物。製備此等醫藥調配物之方法包括使唑尼沙胺與一安排用於控制唑尼沙胺之溶解概況之適宜賦形劑混合。治療方法包括將該等醫藥調配物投與需要此治療之患者。