John C. McKew;Katherine L. Lee;Lihren Chen;Richard Vargas;James D. Clark;Cara Williams;Valerie Clerin;Suzana Marusic;Kevin Pong
发明人:
John C. McKew,Katherine L. Lee,Lihren Chen,Richard Vargas,James D. Clark,Cara Williams,Valerie Clerin,Suzana Marusic,Kevin Pong
申请号：
US12488182
公开号：
US08283373B2
申请日:
2009.06.19
申请国别(地区):
US
年份:
2012
代理人:
摘要：
This invention provides chemical inhibitors of the activity of various phospholipase enzymes, particularly cytosolic phospholipase A2 enzymes (cPLA2), more particularly including inhibitors of cytosolic phospholipase A2 alpha enzymes (cPLA2α). In some embodiments, the inhibitors have the Formula I:wherein the constituent variables are as defined herein.
