The present disclosure relates to milk-based nutritional compositions comprising lactoferrin and/or a prebiotic component, wherein, when combined, the lactoferrin and prebiotic component may exhibit additive or synergistic beneficial effects on the health and development of a pediatric subject. The disclosure further relates to methods comprising the administration of said milk-based nutritional compositions to pediatric subjects.Los compuestos de la presente invención se refieren a compuestos de cefem 2?sustituidos, que tienen un amplio espectro antimicrobiano, en particular exhiben una potente actividad antimicrobiana contra bacterias Gram negativas que producen beta?lactamasa y composiciones farmacéuticas que los comprenden
