A biopsy system comprises a control module, a localization assembly, a biopsy device, and a targeting cube. The biopsy device comprises a holster portion and a probe. The probe and/or other associated components are configured to selectively couple with a targeting cube that is configured to selectively couple with a grid plate having apertures for receiving the targeting cube. The targeting cube comprises a body defined by faces. The targeting cube further comprises guide holes that originate and terminate at the faces and pass through the body of the targeting cube to provide passageways through the targeting cube. The intersections of the faces of the targeting cube comprise edges that are comprised of elastomeric material. The elastomeric edges allow for compression and may thus provide a secure fit with a wide range of grid plates having openings of various shapes and sizes.
