An IV set can include an air stop membrane and one or more additional components including a zero dead space luer access device a vent cap a bubble removal component an antimicrobial coating insert or filter or a precision flow controller. An air stop membrane can be used within the IV set to maintain a fluid column within the IV set downstream of the membrane even after a fluid bag has emptied. By maintaining a fluid column downstream of the membrane air is prevented from entering into the tubing that couples the IV set to a vascular access device. For this reason once a fluid bag has emptied a new fluid bag can be coupled to the IV set without needing to re prime the IV set. Therefore a clinician need not be present as a fluid bag is emptying to ensure that air does not enter the tubing.
