Amide compounds, their pharmaceutical compositions, their preparation method and their uses

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专利权人:

Li Chen;Xing Fan;Renhai Chen;Yaqiu Long;Dongzhi Feng

发明人:

Yaqiu Long,Xing Fan,Dongzhi Feng,Li Chen,Renhai Chen

申请号：

US13123455

公开号：

US08410094B2

申请日:

2009.09.18

申请国别(地区):

US

年份:

2013

代理人:

摘要：

The present invention pertains to the field of pharmaceutical chemistry and discloses 8-(3-aminopropyl)-3-exo-8-azabicyclo[3.2.1]octane-3-amino amide compounds represented by formula I, the pharmaceutical compositions, the preparation method and the use thereof. Such compounds or pharmaceutically acceptable salts thereof can be used as an antagonist of CCR5 in preparing medicaments for treating diseases mediated by CCR5, particularly HIV infection, asthma, rheumatoid arthritis, autoimmune diseases and chronic obstructive pulmonary diseases (COPD).

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中国工程科技知识中心

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