Provided herein are 2,5-disubstituted arylsulfonamide CCR3 antagonists of Formula (Ia) or (II), and pharmaceutical compositions thereof: wherein X, Y, Z, and R 1 - R 5 are as defined herein. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a CCR3 -mediated disorder, disease, or condition.