BOCK, MARK G,CHIKKANNA, DINESH,MCCARTHY, CLIVE,MOEBITZ, HENRIK,PANDIT, CHETAN
申请号：
NZ59956510
公开号：
NZ599565A
申请日:
2010.11.02
申请国别(地区):
NZ
年份:
2013
代理人:
摘要：
599565 The present disclosure relates to compounds of Formula (IA) Where R1a, R1b, X, R2a, R2b, W, R3, R4, and R5 are as defined herein as well as pharmaceutically acceptable salts thereof. The compounds have been shown to act as MEK inhibitors which may be useful in the treatment of hyperproliferative diseases, like cancer and inflammation. Examples of compounds are: Cyclopropanesulfonic acid [7-(2-fluoro-4-iodo-phenylamino)-6-methyl-5-oxo-2, 3-dihydro-5H-oxazolo[3,2-a]pyridin-8-yl]-amide； 2-Hydroxymethyl-cyclopropanesulfonic acid [7-(2-fluoro-4-iodophenylamino)-6-methyl-5-oxo-2,3-dihydro-5H-oxazolo[3,2-a]pyridin-8-yl]-amide and 1-(2-Hydroxy-ethyl)-cyclopropanesulfonic acid [7-(2-fluoro-4-iodophenylamino)-6-methyl-5-oxo-2,3-dihydro-5H-oxazolo[3,2-a]pyridin-8-yl]-amide.
