MULLIS, KARY, B.,VIVEKANANDA, JEEVALATHA,KIEL, JOHNATHAN, LLOYD,COOK, RONALD, M.
申请号：
EP10772762
公开号：
EP2430033A4
申请日:
2010.05.05
申请国别(地区):
EP
年份:
2012
代理人:
摘要：
Methods and compositions for immediately immunizing an individual against any molecule or compound are provided. The present invention is directed to an immunity linker with at least two sites (1) at least one first binding site that binds to an immune response component in an individual, and (2) at least one second binding site that binds specifically to a desired compound or molecule, the target. The second binding sites are preferably thiolated aptamers that have the benefit of increased stability, resistance to degradation and longer circulating half life. Methods of making and using pharmaceutical compositions including immunity linker molecules having a thiolated aptamer are also provided.
