Sustained release lipid initial preparation of GnRH derivative and pharmaceutical composition containing the same

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专利权人:

チョン クン ダン ファーマシューティカル コーポレーション

发明人:

ユン、サン フィル,コ、キ ソン,ユ、ハ ナ,ベク、ヒェ ジュン,ヤン、ウォン キュ,コ、ジン ヨン,パク、ソ ヒュン,ジュン、スン ブム,アン、スン ウォン,キ、ミン ヒョ

申请号：

JP2015550323

公开号：

JP6078660B2

申请日:

2013.12.27

申请国别(地区):

JP

年份:

2017

代理人:

摘要：

Disclosed is a pharmaceutical composition, comprising: a) at least one sorbitan unsaturated fatty acid ester having a polar head with at least two or more &mdash；OH (hydroxyl) groups； b) at least one phospholipid； c) at least one liquid crystal hardener which is free of an ionizable group and has a triacyl group with 15 to 40 carbon atoms or a carbon ring structure in a hydrophobic moiety； and d) at least one GnRH (gonadotropin-releasing hormone) analogue as a pharmacologically active substance, wherein said lipid pre-concentrate exists as a liquid phase in absence of aqueous fluid and forms into a liquid crystal in presence of aqueous fluid. The pharmaceutical composition is configured to enhance the sustained release of the pharmacologically active substance GnRH analogue.

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中国工程科技知识中心

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http://www.ckcest.cn/home/