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HISTIDINE ENGINEERED LIGHT CHAIN ANTIBODIES AND GENETICALLY MODIFIED RODENTS FOR GENERATING THE SAME
专利权人:
发明人:
申请号:
EP15151655.6
公开号:
EP2883449B1
申请日:
2013.03.15
申请国别(地区):
EP
年份:
2018
代理人:
摘要:
A genetically modified non-human animal is provided, wherein the non-human animal expresses an antibody repertoire capable of pH dependent binding to antigens upon immunization. A genetically modified non-human animal is provided that expresses a single light chain variable domain derived from a single rearranged light chain variable region gene in the germline of the non-human animal, wherein the single rearranged light chain variable region gene comprises a substitution of at least one non-histidine encoding codon with a histidine encoding codon. Methods of making non-human animals that express antibodies comprising a histidine-containing universal light chain are provided.
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中国工程科技知识中心
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http://www.ckcest.cn/home/

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