Xiaodong Wang,Dehui Zhang,Dmitri Kireev,Henry Shelton Earp, III
申请号：
US15765168
公开号：
US20180297977A1
申请日:
2016.09.30
申请国别(地区):
US
年份:
2018
代理人:
摘要：
This invention is in the area of improved therapeutic combinations for and methods of treating selected cancers using selected pyrimidine compounds having pan-TAM or Mer/Axl dual receptor tyrosine kinase inhibitory activity in combination with immune checkpoint inhibitors. In one aspect, an improved treatment for select cancers is disclosed using selected pyrimidine compounds described herein in combination with an immune checkpoint inhibitor, for example, a cytotoxic T-lymphocyte-associated protein 4 (CTLA4) inhibitor, a programmed cell death protein 1 (PD1) inhibitor, or a programmed death-ligand 1 (PDL-1) inhibitor, or combination thereof.
