Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8 The compositions and methods have use in the treatment of autoimmunity, inflammation allergy, asthma, graft rejection, graft versus host disease, infection, sepsis, cancer and immunodeficiency.本發明提供藉由類鐸受體(TOLL-LIKE RECEPTOR)TLR7及/或TLR8用於調節信號轉導之組合物及方法。該等組合物及方法係用於治療自身免疫性、炎症性過敏反應、哮喘、移植排斥、移植物對抗宿主疾病、感染、敗血症、癌症及免疫缺陷。