1. A liposome in which is encapsulated an RNA encoding an immunogen of interest, wherein the liposome comprises at least one lipid, which comprises a polyethylene glycol portion, so that the polyethylene glycol is present on the outer surface of liposomes, wherein the average molecular weight polyethylene glycol is from 1 kDa to 3 kDa. 2. The liposome of claim 1, comprising PEG-DMG and / or a lipid of the formula (X): where: Z denotes a component in a hydrophilic head group selected from PEG and polymers based on poly (oxazoline), poly (ethylene oxide), poly (vinyl alcohol), poly (glycerol), poly (N-vinylpyrrolidone), poly [N- (2-hydroxypropyl) methacrylamide], and poly (amino acids), wherein the polymer may be linear or branched, and wherein the polymer may be optionally substituted Z is polymerized subunits n n represents a number average polymerization degree of from 10 to 200 units of Z (and can optimize I for different groups Z) Lneobyazatelno Calkilenovym substituted or Cgeteroalkilenovym linker, including zero, one or two of the ether (e.g., -O-), ester (e.g., -C (O) O-), succinate (e.g., - O (O) C-CH-CH-C (O) O-)), carbamate (e.g., -OC (O) -NR-), carbonate (e.g., -OC (O) O-), urea (e.g. , -NRC (O) NR -), an amine (e.g., -NR-), an amide (e.g., -C (O) NR-), imine (e.g., -C (NR ) -), thioether (e.g. , -S-), xanthate (e.g., -OC (S) S-) and phosphodiester (e.g., -OP (O) O-) wherein R is independently selected from -H, -NH-, -H, -O -, -S-, phosphate or optionally substituted Calkilena Hee Xneza pendently selected from carbon or heteroatoms selected from -NH-, -O-, -S- or phosphate Au Aili independently selected from Ci ^ alkyl and alkenyl Calkinila where Au Amogut be identical or different, or Au atom with Avmeste1. Липосома, в которую инкапсулирована РНК, кодирующая представляющий интерес иммуноген, причем липосома содержит по меньшей мере один липид, который включает полиэтиленгликолевую часть, так что полиэтиленгликоль присутствует на внешней поверхности липосо
