BARBARA PLAIMAUER,FREDERIK DENORME,FRIEDRICH SCHEIFLINGER,HANSPETER ROTTENSTEINER,SIMON DE MEYER
申请号：
BR112017025142
公开号：
BR112017025142A2
申请日:
2016.05.26
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
Provided herein are methods for recanalization of occluded blood vessels in a subject having an infarction. The method includes a step of administering to the subject a therapeutically effective amount of isolated ADAMTS13 protein at particular dosages and ranges of times after detection of the infarction. As described herein, ADAMTS13 advantageously recanalizes occluded blood vessels and reduces infarction size, even when administered a prolonged period after stable occlusion. Accordingly, such methods and compositions are useful for the treatment of infractions caused by blood vessel occlusion.
