The object of the present invention is to provide a novel RAGE message inhibitor. The RAGE message inhibitor of the present invention contains a compound selected from the group consisting of Japanese roadside green, sage clover, frankincense, larynx, kumquat, camphor, European white willow, false leaf tree, sassafras, camphor, ginger flower, An extract of one or more plants of the plant group consisting of purslane, quinoa and papaya is used as an active ingredient.本發明之課題在於提供一種新穎RAGE訊息抑制劑。本發明之RAGE訊息抑制劑含有選自由日本路邊青、快樂鼠尾草、齒葉乳香、毛喉鞘蕊花、金柑、樟樹、歐洲白柳、假葉樹、薜荔、黃樟、薑花、冬馬齒莧、藜及番木瓜所組成之植物群中之1種或2種以上之植物之萃取物作為有效成分。
