Processes for the preparation of sofosbuvir and intermediates thereof

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专利权人:

TEVA PHARMACEUTICALS INTERNATIONAL GMBH

发明人:

Vinod Kumar Kansal,Dhirenkumar Natvarial Mistry,Srinivas Achanta,Sundaraselvan Ariyamuthu,Miteshgir Kanchangir Goswami,Venkata Subbarao Yazali

申请号：

US15577622

公开号：

US10676498B2

申请日:

2016.06.02

申请国别(地区):

US

年份:

2020

代理人:

摘要：

The present disclosure provides procedures and intermediates for the preparation of Sofosbuvir, comprising the step of reacting a compound of formula 2: wherein R1 and R2 can independently be hydrogen or halogen, provided that at least one of R1 and R2 is a halogen.

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