AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH;THE BRIGHAM AND WOMEN'S HOSPITAL, INC.;NATIONAL UNIVERSITY OF SINGAPORE
发明人:
LIU, Bee,TENEN, Daniel,CHAI, Li,CHIA, Cheng San,POULSEN, Anders
申请号：
SG11201809315Y
公开号：
SG11201809315YA
申请日:
2017.04.28
申请国别(地区):
SG
年份:
2018
代理人:
摘要：
The present invention provides, in certain embodiments, isolated peptides and pharmaceutical compositions comprising isolated peptides that bind to retinoblastoma binding protein 4 RBBp4 such that, the binding blocks the SALL4-RBBp4 interaction. Methods of inhibiting binding of SALL4 with RBBp4 and methods for treating a subject having a disorder mediated by a dysregulation of SALL4 are also provided.
