JUDD E. SHELLITO,ALISTAIR JOHN RAMSAY,DAVID A. WELSH,SANBAO RUAN,YANG CAI
申请号：
US15305190
公开号：
US20170042988A1
申请日:
2015.05.04
申请国别(地区):
US
年份:
2017
代理人:
摘要：
A surface protein of the murine fungal pathogen Pneumocystis murina can be used to generate an immune response in a recipient animal or human that provides prophylactic protection and an anti-fungal activity in subjects already infected with a Pneumocystis species. Further, the disclosure provides novel polypeptides or peptides derived from the P. murina surface protein Surface Peptidase 1 (SPD-1) that are useful, alone or in combination with the SPD-1 polypeptide, in compositions and methods for the generation of an anti-Pneumocystis immune reaction by a recipient subject. The compositions and methods of the disclosure provide advantageous alternatives to available immunogenic determinants for the treatment or prevention of fungal pneumonia.
