A polyclonal antibody composition prepared from eggs of immunized hens is usedtotreat C. difficile infections. Respective groups of hens are immunized withToxin A or Toxin Bof Clostridium difficile or a Clostridium difficile spore preparation. Thepolyclonal antibodiesare recovered from eggs pooled from the immunized hens and the resultingpowder isadministered in a therapeutically effective amount to individuals infectedwith or suspected ofbeing infected with C. difficile.