Professional Compounding Centers of America (PCCA)
发明人:
Daniel Banov
申请号：
GB201605961
公开号：
GB2542871A
申请日:
2016.04.07
申请国别(地区):
GB
年份:
2017
代理人:
摘要：
Composition for improving active pharmaceutical ingredient (API) solubilisation, comprising a compound produced from the catalytic reaction of glucose and a castor oil derivative, an olive oil derivative, and at least one active pharmaceutical ingredient. Preferably the compound produced from the catalytic reaction of glucose and a castor oil derivative is heptyl glucoside, heptanol, or a mixture thereof. The olive oil derivative may be olive oil glycereth-8 esters, or polyglyceryl-3 olivate phosphate, polyglyceryl-3 pentaolivate, polyglyceryl-3 cetearyl ether olivate, or mixtures thereof. A preferred olive oil derivative is olive oil glycereth-8 esters. Preferably the API is a steroid hormone, especially estriol, estradiol, or testosterone. The composition may be in the form of a liquid, cream, paste, gel, lotion, patch, tape, plaster, or combination thereof. Compositions according to the present invention may be used for the transdermal administration of hormones, especially in hormone replacement therapy.
