The present invention relates to a docosahexaenoic acid ester including an alcohol selected from among the group made up of nicotinol panthenol inositol isosorbide and isosorbide mononitrate or one of the pharmaceutically acceptable salts enantiomers diastereoisomers or mixtures thereof including racemic mixtures for the use thereof as a drug for the prophylactic and/or curative treatment of drepanocytosis.