Systems and methods for patient monitoring that include receiving a set first of SpO2 readings from a first sensor over a time period, receiving a set of second SpO2 readings from a second sensor over the time period, calculating an average first SpO2 value based on some or all of the first SpO2 readings, calculating an average second SpO2 value based on some or all of the second SpO2 readings, calculating a differential value based some or all of the first SpO2 readings and some or all of the second SpO2 readings, and determining a screen result based upon the average first SpO2 value, the average second SpO2 value, and the differential value. The differential value may be, for example, an average differential value or an accumulation differential value.
