The present disclosure relates to methods for treating, preventing and improving the condition and aesthetic appearance of skin, particularly, treating, preventing, ameliorating, reducing and/or eliminating fine lines and/or wrinkles of skin, by application of one or a combination of natural compounds or extracts that stimulate MAGP-1 expression and which improves the appearance of aged and/or photodamaged skin. The compositions of the invention are topically applied to the skin, or are delivered by directed means to a site in need thereof in an amount effective to improve the condition and aesthetic appearance of skin.本發明係關於一種用於治療、預防及改善皮膚狀況及美學外觀,特定言之係治療、預防、改善、減少及/或消除皮膚細紋及/或皺紋之方法,其係藉由施用一種刺激MAGP-1表現並改善老化及/或光損傷皮膚之外觀之天然化合物或萃取物或其組合而實現。本發明組合物係以有效改善皮膚狀況及美學外觀之用量局部施用至皮膚,或藉由定向裝置遞送至有此需要之部位。