Ghiani, Simona,Maiocchi, Alessandro,Caminiti, Lara,Miragoli, Luigi
申请号：
AU2014273118
公开号：
AU2014273118B2
申请日:
2014.05.28
申请国别(地区):
AU
年份:
2019
代理人:
摘要：
The present invention discloses a solid lipid nanoparticle (SLN) comprising: a) a solid lipid core comprising at least a glyceride and/or at least a fatty acid； b) a mixture of amphiphilic components forming a shell around said core a)； c) an alkaline-earth complex with a compound of formula I and/or II: d) at least a fluorescent dye selected from: a cyanine fluorescent dye and /or a polyetherocyclic compound selected from: coumarin, pyrano, quinoline, pyranoquinoline, indole and pyranoindole derivates in acid form or a pharmaceutically acceptable salt thereof. These nanoparticles allow a prolonged blood circulation half-life, show enhanced photostability and improved fluorescence signal. The dye is preserved from degradation and improves the fluorescent quantum yield.
