A system and method for monitoring cerebral compliance of a patient by placing a first pressure sensor in a first sub-dural location, preferably a sub-meningeal location, within the brain of the patient and placing at least a second pressure sensor in a second sub-dural location, preferably a sub-meningeal location, within the brain which is different from the first location. At least one parameter from each of the signals derived from the pressure sensors is compared to estimate cerebral compliance for the patient. Alternatively, at least a single pressure sensor is utilized with a generator of reference signals having at least two different frequencies. Preferably, any change in cerebral compliance is detected by determining a change in the compared parameter, and a perceptible indication is generated when cerebral compliance deviates beyond a pre-selected value.
