PROBLEM TO BE SOLVED: To provide a therapeutic composition for failure of central nervous system myelination generated by hyperfunction of a PLP1 protein, a treatment medicine containing the therapeutic composition, and a method of promoting central nervous system myelination.SOLUTION: The therapeutic composition for failure of central nervous system myelination includes an MAPK pathway activation inhibitor, for example an MAPKK activity inhibitor. A patient of failure of central nervous system myelination is administered with a treatment medicine containing the therapeutic composition, thereby a failure symtom of central nervous system myelination is promoted, and is improved.COPYRIGHT: (C)2010,JPO&INPIT【課題】PLP1タンパク質の機能亢進によって生じる中枢神経髄鞘形成不全の治療用組成物、その治療用組成物を含有する治療用薬剤、および中枢神経髄鞘形成促進方法を提供すること。【解決手段】中枢神経髄鞘形成不全の治療用組成物に、MAPK経路活性化阻害物質、例えばMAPKK活性阻害物質を含有させる。その治療用組成物を含有する治療用薬剤を中枢神経髄鞘形成不全の患者に投与することによって、中枢神経髄鞘形成を促進し、中枢神経髄鞘形成不全症状を改善することができる。【選択図】図2
