PROBLEM TO BE SOLVED: To provide a DNA vaccine effective for the treatment or prophylaxis of cancer, which targets a tumor angiogenesis-related factor and has a reduced risk of an adverse influence on the normal blood vessel function.SOLUTION: A DNA vaccine comprises an expression vector encoding a chimeric Hepatitis B virus core antigen polypeptide inserted with an amino acid sequence comprising a specific epitope of VEGF, a tumor angiogenesis-related factor, and/or a specific epitope of angiopoietin-2, where the amino acid sequence comprising the specific epitope is inserted between the amino acid residues 80 and 81 of the hepatitis B virus core antigen polypeptide.SELECTED DRAWING: NoneCOPYRIGHT: (C)2018,JPO&INPIT【課題】正常な血管機能への悪影響のリスクが低減された腫瘍血管新生関連因子を標的する癌の治療や予防に有効なＤＮＡワクチンの提供。【解決手段】腫瘍血管新生関連因子であるＶＥＧＦの特異的エピトープ及び／又はアンギオポエチン－２の特異的エピトープを含むアミノ酸配列が挿入されたキメラＢ型肝炎ウイルスコア抗原ポリペプチドをコードする発現ベクターを含み、該特異的エピトープを含むアミノ酸配列が、Ｂ型肝炎ウイルスコア抗原ポリペプチドのアミノ酸残基８０と８１の間に挿入されているＤＮＡワクチン。【選択図】なし
