LEAKE DEVIN,FEDOROV YURIY,REYNOLDS ANGELA,KHVOROVA ANASTASIA,MARSHALL WILLIAM
申请号：
US20040019831
公开号：
US2005223427(A1)
申请日:
2004.12.22
申请国别(地区):
美国
年份:
2005
代理人:
摘要：
Methods and compositions for performing RNA interference with decreased off-target effects are provided The methods and compositions permit effective and efficient applications of RNA interference to applications such as diagnostics and therapeutics through the use of modifications to the siRNA. Uniquely modified siRNAs have been developed that reduce off-target effects incurred in gene-silencing. The modifications comprise 2'-O-alkyl or mismatch modification(s) at specific positions on the sense and/or antisense strands.
