Lu, Tianbao,ALEXANDER, Richard,CONNORS, Richard, W.,CUMMINGS, Maxwell, D.,GALEMMO, Robert, A.,JOHNSON, Dana, L.,Khalil, Ehab,LEONARD, Kristi, A.,MARKOTAN, Thomas, P.,MARONEY, Anna, C.,TUMAN, Robert, W
申请号:
DK06847749
公开号:
DK1966214T3
申请日:
2006.12.18
申请国别(地区):
DK
年份:
2017
代理人:
摘要:
The invention is directed to triazolopyridazine compounds of Formula I: where R1, R5, R6, R7, R8, and A are as defined herein, the use of such compounds as protein tyrosine kinase modulators, particularly inhibitors of c-Met, and the use of such compounds to reduce or inhibit kinase activity of c-Met in a cell or a subject, and modulate c-Met expression in a cell or subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to c-Met. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as cancers and other cell proliferative disorders.