The invention is directed to an perfusion device for a biological tissue comprising a holder (1) and a plurality of hollow penetration structures (2), wherein the hollow penetration structures (2) are provided with a tip (3) capable of penetrating into the biological tissue and at least one orifice (4) which has fluid communication through the hollow penetration structure (2) and the holder (1) characterized in that the hollow penetration structures (2) consist of at least one polymer.