A priming cap includes a conduit housing and a resilient member. The conduit housing further includes an upper housing, a lower housing coupled to the upper housing, a fluid passageway extending through the upper housing and the lower housing； and a plug positioned within the upper housing. The conduit housing can define a valve activation member configured to open and close a medical connector. The resilient member can include a retaining feature to secure the priming cap to the medical connector.
