A capsule medical device guidance system includes: an imaging unit arranged inside a capsule medical device; a guidance unit configured to guide the capsule medical device inside a subject; a display unit including a screen is displayed; a first operation input unit configured to input first instruction information for changing at least one of a position and a posture of the capsule medical device; a second operation input unit configured to input second instruction information for rotating within the screen, the image displayed on the screen, around a center of the image; a guidance controller configured to control the guidance unit so as to change at least one of the position and the posture of the capsule medical device, based on the first instruction information; and a display controller configured to control a direction of the image displayed on the screen based on the second instruction information.