PROBLEM TO BE SOLVED: To develop a technique that can enhance the natural immunity activating ability of single strand CpG DNA oligonucleotide.SOLUTION: A natural immunity activating agent according to the present invention is a natural immunity activating agent that contains human CXCL14 chemokine protein or a variant protein thereof or contains the protein and single strand DNA delivered to endosome or lysosome of an antigen-presenting cell.SELECTED DRAWING: NoneCOPYRIGHT: (C)2018,JPO&INPIT【課題】一本鎖CpG DNAオリゴヌクレオチドの自然免疫賦活能を増強させ得る技術の開発。【解決手段】本発明に係る自然免疫賦活剤は、ヒトCXCL14ケモカインタンパク質又はその変異型タンパク質を含む、或いは、当該タンパク質と抗原提示細胞のエンドソーム又はリソソームに送達される一本鎖DNAとを含む、自然免疫賦活剤等である。【選択図】なし