This invention provides thieno[2,3-d]pyrimidine derivatives containing isoxazole heterocycle represented by formula (I), or pharmaceutically acceptable salts thereofWherein: R1 and R2 may be the same or different and is independently to each other selected from H, C1-6 alkyl, C1-6 alkoxy, halo-C1-6 alkyl or halo-C1-6 alkoxy, aryl group optionally substituted by R7 or heteroaryl group optionally substituted by R8 or R1 and R2 together with the carbon atoms to which they are attached, may form a 4- to 6-membered carbocyclic ring or heterocyclic ring said carbocyclic ring or heterocyclic ring is optionally substituted by H, C1-6 alkyl, halogen, nitro, or amino said heterocyclic ring contains at least one heteroatom selected from N, O or S Z is -NR6-, C(R6)2, -S- or -O-, in which R5 is H or C1-6 alkyl, and R6 is the same or different, selected from H, C1-6 alkyl or hydroxyl substituted C1-6 alkyl R3 is selected from H, halogen, C1-6 alkyl, C1-6 alkoxy, halo-C1-6 alkyl or halo-C1-6 alkoxy n is an integer of 0-5 R4 is selected from H, C1-6 alkyl, C1-6 alkoxy or halo-C1-6 alkyl, aryl group optionally substituted by R9, or heteroarylgroup optionally substituted by R10 R7, R8, R9 or R10 independently to each other, is selected from H, hydroxy, mercapto, cyano, amino, nitro, halogen, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, carboxy, halo-C1-6 alkyl or halo-C1-6 alkoxy. This invention also provides the preparation method and medicinal uses of the compounds of formula (I) and pharmaceutically acceptable salts thereof. and this class of compounds can be used as medicants or lead compounds for the treatment of diseases such as tumors, cancers.
