A scalpel handle sheath includes a body defining a handle-receiving cavity open to a first end of the body through a narrowed sleeve region, the body further defining a flexible arm adjacent the first end with a first boss extending inwardly therefrom adjacent the sleeve region. The sheath further includes a shield coupled with the body and slideable between a retracted position and a removal position. The shield defines an edge applying an inward force on the flexible arm during movement of the shield from toward the retracted position to the removal position and a removal flange extending within the shield and passing the first end of the body during movement of the shield from the toward retracted position to the removal position.
