EUROPEAN EGYPTIAN PHARMACEUTICAL INDUSTRIES (EEPI);MAHMOUD, MONA BAKR MOHAMED;HELMY, SHERINE HASSAN ABBAS;NANOTECH FOR PHOTOELECTRONICS RESEARCH
发明人:
MAHMOUD, MONA BAKR MOHAMED,HELMY, SHERINE HASSAN ABBAS
申请号：
EP13876801
公开号：
EP2964205A4
申请日:
2013.10.29
申请国别(地区):
EP
年份:
2016
代理人:
摘要：
New formulas of Iron oxides nanoparticles capped with a mixture of multivitamins such as folic acid, Nicotinic acid (vitamin B9) and Ascorbic acid (vitamin C) has been developed for the rapid and efficient treatment of life threatening iron-deficiency anemia. Small single dose of iron oxides-multivitamin nano-composite as low as 8.3 mg elemental iron per does is sufficient to increase the hemoglobin level from 4.4 g/dl up to 14.6 g/dl within only four days after administration. The multivitamin which used in this nano-composite enhances iron absorption significantly and elevated the concentration of hemoglobin. Two dosage forms of Iron nano-composites have been developed, gel capsules and aqueous solution for oral administration. Animal trials studies reveal that introducing single dose of Iron Oxide-vitamin nano-composites containing 8.6 mg elemental iron per kg rat body weight is sufficient to correct the hemoglobin level and cure Anemia via oral administration.
