There is provided herein derivative hyperbranched poly glycerine (" dHPG "). DHPG includes kernel and shell, the core includes the hyperbranched poly glycerine derived from C1-C20 alkyl chain, the shell includes at least one hydrophilic with the hydroxy combining of kernel, and wherein hyperbranched poly glycerine includes about 1 mole-about 200 moles of at least one hydrophilic. Drug or other biologically-active moieties are delivered to the reagent of the urinary tract, alimentary canal, air flue, vaginal canal and cervix and cavum peritoneale with effect what by dHPG, to treat the indication of such as cancer, this what treatment of cancer that comes in handy, or manufacture drug, the drug prepare the pharmaceutical composition for the treatment of cancer with what； Or as pretreatment or combination therapy to improve the ingestion of medicines in tissue. Further it is provided that the method for manufacture dHPG.本文提供了衍生的超支化聚丙三醇(“dHPG”)。dHPG包含內核和外殼，所述核心包含用C1-C20烷基鏈衍生的超支化聚丙三醇，所述外殼包含至少一種與內核的羥基結合的親水性取代基，其中超支化聚丙三醇包含約1摩爾-約200摩爾的所述至少一種親水性取代基。dHPG用作用於將藥物或其他的生物活性部分遞送至泌尿道、消化道、氣道、陰道腔和子宮頸、以及腹膜腔的試劑，以治療諸如癌症的適應症，這可能有用於癌症治療，或製造藥物，所述藥物用於製備治療癌症的藥物組合物；或用作預處理或聯合治療以改善組織中的藥物攝取。此外，提供了製造dHPG的方法。
