The present invention comprises QEP or a QEP derivative thereof for use in the prevention or treatment of a disease or disorder caused by physiologically linked or associated glucose and / or galactose intake It relates to a pharmaceutical composition to be administered under high sugar conditions, comprising a (poly) peptide comprising it, a nucleic acid molecule encoding said (poly) peptide, or a vector comprising said nucleic acid molecule. Furthermore, the pharmaceutical composition of the present invention is for use to increase insulin sensitivity. The present invention further relates to a food composition comprising the (poly) peptide. The invention also relates to a method for screening and / or identifying suitable compounds for preventing or treating said disease or disorder under high sugar conditions. The present invention may further inhibit (SGLT1-mediated) glucose and / or galactose uptake into cells expressing ODC and / or inhibition of inhibitors of glucose and / or galactose uptake into cells expressing ODC. It relates to a method for screening and / or identifying compounds that modulate ornithine decarboxylase (ODC) that can enhance the effect. The invention further provides a method for predicting patient non-response or response to said (poly) peptide, a method for stratifying patients for prevention or treatment with said (poly) peptide, and said disease or disorder Relates to a kit for determining whether a patient suffering from is non-responder or responder to said polypeptide. The invention further relates to a method for developing and / or planning suitable compounds / drugs for preventing or treating said diseases or disorders.本発明は、グルコース及び／又はガラクトース摂取の生理学的にリンクされるか又は関連付けされることにより引起される疾患又は障害の予防又は治療への使用のための、ＱＥＰ又はそのＱＥＰ誘導体を含むか又はそれから成る（ポリ）ペプチド、前記（ポリ）ペプチドをコードする核酸分子、又は前記核酸分子を含むベクターを含む、高糖条件下で投与されるべき医薬組成物に関する。さらに、本発明の医薬組成物は、インスリン感受性を高めるのに使用するためである。本発明はさらに、前記（ポリ）ペプチドを含む食品組成物に関する。本発明はまた、高糖条件下で前記疾患又は障害を予防するか又は治療するために適切な化合物をスクリーニングし、そして／又は同定するための方法に関す
